Stimulating G Protein–Coupled Receptors

A direct and functional interaction between the trimeric G protein Go and Rab5 in G proteincoupled receptor signaling

Stimulating G protein-coupled receptors: cure or cause for heart failure?

Historically there has been intense interest in restoring to the failing heart the ability to improve contractility to normal levels. This concept, which has been pursued with almost religious zeal for the last half century, is based on the intuitive assumption that the defect in heart failure resides at the end point, which is defective myocyte contraction. This concept was given additional im...

G-protein-coupled receptors.

G-Protein-coupled receptors mediate many of the hypnotic and analgesic actions of the drugs employed in anesthesia. Notably, opioid agonists represent the most successful and efficacious class of analgesic agents employed over the last century. Also, major clinical advances have been made by the study of alpha(2) adrenoceptor agonists, which possess both hypnotic and analgesic qualities that ar...

G Protein-coupled receptors

G protein-coupled receptors and heterotrimeric G proteins can diffuse laterally in the plasma membrane such that one receptor can catalyze the activation (GDP/GTP exchange) of multiple G proteins. In some cases, these processes are fast enough to support molecular signal amplification, where a single receptor maintains the activation of multiple G proteins at steady-state. Amplification in cell...

Stimulating Skin Receptors for Tactile Display

recognized the need for more realistic tactile display in addition to touch and non-touch display and force display. Researchers have proposed various mechanisms of pin or vibrator arrays to present the sensations of 3D local shapes, fine textures, and slippage of grasped objects. Watanabe demonstrated an interesting method of controlling surface roughness using ultrasonic vibration. In all the...